Alterations in Serum Biochemical Parameters, Lipid Profile Markers, and Atherogenic Index in Patients with Vitamin D Deficiency

Background and Objective: Vitamin D deficiency is a global health problem caused mainly by obesity, lifestyle changes, and reduced sun exposure. This study aimed to evaluate the effect of vitamin D deficiency on lipid profile and biochemical biomarkers in men and women. Materials and Methods: The experimentation was carried out on 24 voluntary individuals who were divided into four groups: Two groups of healthy men and women (controls), and the other two groups were men and women vit D deficiency. All the volunteers were subjected to an estimation of the lipid profile, biochemical parameters. Data are presented as mean±SEM and compared using Student’s t-test in Minitab; p<0.05 was considered significant. Results: There was a significant increase (p<0.001) in TC, LDL-C, and Atherogenic index (AI) were highly significantly raised (p<0.01). At the same time, the HDL-C level is significantly decreased (p<0.001) for vit D deficiency groups compared to the control one. However, the biochemical parameters didn’t change. The biochemical results demonstrated that there was a significant change (p<0.05) in Blood glucose, urea, and creatinine levels in vit D deficiency patients compared to the controls. Conclusion: The vitamin D deficiency may induce severe alterations in lipid profiles which cause an increase in cardiovascular risk for this population.