Anti-diabetic and Anti-oxidative Activities of Algerian Oudneya africana Extract in Alloxan Induced Diabetic Rats

ABSTRACT

Background and Objectives: Oudneya africanais is a plant widely used in the treatment of a variety of diabetes disorders in Algerian traditional medicine. However, the underlying mechanism has remained unclear. This study focused on the research of the anti-diabetic and antioxidant effects of the aqueous extracts of the leaves of Oudneya africana. Materials and Method: The study carried out on 12 female rats of the Albino Wistar strain divided into three groups; healthy control group, untreated diabetic group, and the diabetic group treated with aqueous extracts of Oudneya africana (AEOa) (400 mg kg^–1 b.wt.) for 21 days. Diabetes in rats was induced by Alloxan using a single peritoneal injection of 150 mg kg^–1 dose. Body weight and blood sugar were measured regularly. After 21 days of treatment, the rats were sacrificed and some biochemical parameters were determined. Results: Results clearly showed that the treatment with aqueous extracts of Oudneya africana significantly decreases the blood glucose and improves the transaminases activities (TGO, TGP) of diabetic rats. On the other hand, the administration of the aqueous extract also decreases (p>0.05) the plasma level of uric acid, urea and creatinine. Decrease (p<0.01) in the concentrations of tissues MDA and an increase in the tissues GSH level was observed. On the other hand, histological examination of the pancreatic tissue shows that the aqueous extract of Oudneya africana has a protective effect on the structure and function of Langerhans β cells and improves the histological architecture of the islets of Langerhans. Conclusion: In conclusion, the present study suggests that Oudneya africana has a beneficial effect on the development of diabetes and these complications.